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In an open pneumothorax, there is a passage from the external environment into the pleural space through the chest wall

[8] Unlike pneumonia, asthma and COPD typically present with wheezing, pulmonary edema presents with an abnormal electrocardiogram, cancer and bronchiectasis present with a cough of longer duration, and pulmonary emboli present with acute onset sharp chest pain and shortness of breath

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An instant Cotinine test kit will not give you any indication of how much Cotinine was detected, just that it was present in the sample