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Admissions and ER visits only due to acute exacerbation were included, and admissions due to scheduled surgery, biological treatment, or other examinations were excluded

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METHODS Participants A total of 800 potential Japanese participants (300 cigarette smokers, 300 HTP smokers, and 200 never smokers) were recruited and screened online throughout Japan using a research agency (Asmarq Corp., Tokyo, Japan)

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also noted significantly increased carbonylation of salivary proteins in heavy smokers and non-smokers exposed to cigarette smoking one time

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