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These symptoms, which include irritability, anxiety, difficulty concentrating, increased appetite, restlessness, depression, and insomnia, are classified as affective, somatic, or cognitive by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

Cigarette smoking kills approximately 500,000 Americans each year and smoking-related illnesses cost more than $300 billion each year

These findings highlight the MKK3p38 MAPKPRKN pathway as a mechanistic link between cigarette smoke exposure, mitophagy disruption, and epithelial senescence in COPD

Biological System, Minor and Major Alleles and Minor Allele Frequency of 16 SNPs from Seven Genes (n = 544)

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