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Additionally, metabolic profiling has revealed that suppression of GLS1 induces a compensatory anaplerotic mechanism via pyruvate carboxylase (PC), which allows the release of a glutamine-independent supply of TCA intermediates by catalyzing the transformation of pyruvate to oxaloacetate 153

10.1038/s41388-024-03050-z 151 SuX.DingX.DingC.WangG.FuC.LiuF.et al (2024)

doi:10.1002/brb3.208

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Although branched polyamines offer conformational stability [90], their transfection efficiency is generally lower than that of linear analogues [90]

Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy