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Biotechnology and Food Science 76:3541 Szymanski M (2014) Molecular mechanisms of lead toxicity

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Potential limitations include: Limited long-term human data Variable patient response Cost considerations Need for ongoing monitoring Off-label prescribing considerations These therapies are generally avoided in patients with: Active malignancy Pregnancy or breastfeeding Significant uncontrolled endocrine disease Certain metabolic conditions Monitoring and Safety Where prescribed, monitoring may include: IGF-1 levels Functional recovery Sleep quality Rehabilitation tolerance Adverse effects Overall clinical progress Treatment should always be part of a broader recovery plan rather than a standalone intervention

In panel ( b ), we exponentiated the y-values from panel ( a ) to yield the relative risk curve

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