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Our laboratory has made seminal contributions in demonstrating that by virtue of removing the two detrimental metabolites, homocysteine and S-adenosylhomocysteine (SAH), BHMT-mediated catalysis serves an important role in preventing the development of alcohol-associated liver disease

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Reproducibility across manufacturing batches must be verified through comprehensive analytical characterization

When given by intramuscular injection, the dose bypasses the digestive tract and is absorbed reliably, which matters because dietary B12 absorption depends on stomach acid and a protein called intrinsic factor, both of which decline with age, medication and certain gut conditions

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As an example, reaction of Cd with the sulfhydryl group (SH) in a protein is shown in Figure 3