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While not listed as a direct adverse effect in FDA prescribing information, this cold sensitivity appears linked to the medication's weight loss effects rather than direct temperature regulation changes

Wu M, Zhang J, Gu R, Dai F, Yang D, Zheng Y, et al

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found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses

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