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There is well-established synergy between alcohol and tobacco consumption for oropharyngeal and gastrointestinal (GI) tract cancer [25, 26]

From Emily Posts Etiquette in society, in business, in politics and at home , 1922: A gentleman should not smoke under the following circumstances: When walking on the street with a lady

Beverage-specific additives or byproducts, such as congeners, in alcohol also play an important role in a hangover

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Apart from these well established effects, many other effects are suspected with regard to non malignant diseases and the aggravation of pre-existing conditions or malignous diseases, however new scientific data is needed to confirm these effects

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