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The effect of DSePA administration on RP was studied by subjecting mice to thoracic irradiation (X- or -rays, 18 Gy), treating them with DSePA (2.5 mg/kg body weight for three time a week for 6 months beginning on the day of irradiation) during the post-irradiation period and monitoring the incidence of RP through immunohistochemical and CT analysis (Table 2) [61, 62]

Subcutaneous (SubQ) injections deliver a medication into the fatty tissue just under the skin

CAF isolation: CAFs were isolated by in situ liver perfusion/in vitro digestion and gradient centrifugation

Nonapoptotic forms of cell death induced by taxanes The mitochondrial network is crucial for the modulation of the cross-talk between autophagy and apoptosis and can regulate cell death or survival decision [97]

Discussion Leukaemic blasts freely infiltrate the CNS without undergoing subclonal selection 46

Brain research bulletin