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Organic arsenic compounds were used before the penicillin era for the chemotherapy of syphilis and various protozoan diseases

You could also drink certain herb teas

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Belushi, Speedball Cocaine + PCP: Space, Whack, Space Dust Cocaine + meth: Croak Cocaine + tobacco: Coolie, Geek-Joint Multiple-drug combo: Five way Crack + fentanyl: Dirty Fentanyl, Takeover Most of these mixtures dramatically increase overdose risk, even when someone thinks they know what theyre taking