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In a later study, these investigators reported that the absence of TNF receptors is protective against infiltration of inflammatory cells, breakdown of lung matrix, and air-space enlargement in mice lacking P55 and P75 TNF receptors (TNFRKO mice) after exposure to whole smoke from four 2R1 reference cigarettes five days per week for six months (Churg et al

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'I was devastated when I got COPD, I thought my lungs are going to collapse and I'm going to die because you really feel like you are going to die,' he said