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Hoffman DW, Whitworth CA, Jones-King KL, Rybak LP: Potentiation of ototoxicity by glutathione depletion

Results: in silico results indicated that arbutin showed a good binding affinity for target proteins PI3K/Akt, and Nrf2

Among modifications, disulfide and thioether linkages, N-methylation, and complex modifications show greater co-occurrences across all therapeutic areas