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Certain health conditions like sinus infections, acid reflux, and diabetes can contribute, too

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As discussed earlier, we and others have previously reported that K-ras mutant tumors have an intrinsic inflammatory phenotype that is associated with the activation of the NF-kB pathway and production of a group of inflammatory pro-tumor cytokines ( Taken together, these data suggest a link between TLR-mediated inflammation in COPD and lung cancer progression, introducing TLR/MyD88/NF-kB pathway as a key player in linking COPD to lung cancer