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Products must be under supervision of sales clerk(s) or in sight of the sales clerk.7,8 Establishments are required to post signs stating that sales to minors are prohibited.7,8 The sale of nicotine dispensing devices, including e-cigarettes, to persons under 21 is prohibited.7,8 Delivery sales of nicotine products require certification from the customer, verification of certification by the retailer, notification to the customer of purchase age restriction, confirmation of shipment to the consumer by telephone and use of a delivery service that will verify the age of the person accepting the delivery

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Mechanism of Action and Effects The effects of cannabinoids are largely mediated by the CB1 receptor