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Novel dopamine agonists have been developed and tavapadon, a selective dopamine D1/D5 receptor partial agonist, was shown to be efficacious as monotherapy in early PD and adjunct to levodopa in patients with motor fluctuations

All these diseases are strongly associated with each other, and the manifestation of one often involves the onset of the others 4,5

Association with health risks The consequences of untreated HU extend beyond the biochemical abnormalities associated with elevated UA levels

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genomics 42 , 343353 (2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Gaboriau-Routhiau V, Rakotobe S, Lcuyer E, Mulder I, Lan A, Bridonneau C, Rochet V, Pisi A, De Paepe M, Brandi G, Eberl G, Snel J, Kelly D, Cerf-Bensussan N