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Description

Modulation of CD44 in acute lymphoblastic leukemia identifies functional and phenotypic differences of human B cell precursors

identified a non-inhibitory aptamer against the CRL2ZYG11B complex, employing it as an E3 warhead to construct dual-function ZATACs capable of degrading multiple targets, e.g., HaloTag ( Halo-ZATAC#T3 ) (Fig