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Vascular endothelial growth factor (VEGF) is a star molecule that regulates the mitosis and growth state of endothelial cells (ECs) and can induce apoptosis tolerance in ECs through the external pathway of Fas signaling and the intrinsic pathway of the Bcl-2 protein [32, 33]

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Chutipongtanate A, Prukviwat S, Pongsakul N, Srisala S, Kamanee N, Arpornsujaritkun N, et al

However, during the chronic inflammation, the glial activation causes an increase of ROS production and other neurotoxic mediators, leading a neuronal damage [52]

Endothelial cell dysfunction in a model of oxidative stress

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