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1) and HIV Tat and CS suppress CFTR mRNA (and consequently function) via a common pathway involving TGF- signaling 5,11 , and CS directly suppresses CFTR function by localizing them in aggregosomes 28 , we tried to determine if HIV infection and CS exposure leads to a synergistic suppression of CFTR biogenesis and function

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Once on the ledge, Honnold removed his harness and excess clothing, dipped his hands into a bag of magnesium, blew off the excess, and left its relative safety to face 40 meters of life or death climbing