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Al Aboosi M: Treatment of plane warts by tretinoin-induced irritant reaction

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K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

Mechanistically, IL-23 signaling through its heterodimeric receptor (IL-23R/IL-12R1) activates STAT3 phosphorylation (pSTAT3), which drive their commitment to a Th17-like pathogenic subseta process critical for the production of IL-17A and IL-22 (126), which in turn enhance epithelial permeability and inflammatory infiltration in the gut (127)