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An important caveat when analysing CCA epidemiological studies is the lack of information regarding the incidence and mortality for pCCA

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

Oxidative stress is a key driver of mutagenesis and tumorigenesis through oxidative DNA damage and a significant phenomenon in the conversion of normal cells into cancerous phenotypes, primarily by undermining genomic integrity (Bartek 2011)

Ugeskr Laeger 2015;177:V10140568

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Interactions between genetic variants and environmental factors affect risk of esophageal adenocarcinoma and Barretts esophagus