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To test whether it was feasible to divert the Cys precursors (i.e., Hcy and cystathionine) accumulated in the evolved strain to Cys synthesis and then increase GSH production, the two key genes encoding cystathionine -lyase (-CTLase, CYS3 ) and cystathionine -synthase (-CTSase, CYS4 ) of the Cys biosynthesis pathway were independently or simultaneously overexpressed in the evolved strain under the control of a constitutive promoter (Supplementary Fig

However, pathology does not mimic a thrombosis or embolism that would be observed clinically

Histone post-translational modifications Histone acetylation and deacetylation Histone acetylation, a sophisticated epigenetic modification, plays a vital physiological role in the regulation of gene transcription by modulating the chromatin structure

Infection of a human hepatoma cell line by hepatitis B virus