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In our study, however, 13 C-labelling of lactate was not detectable in human, consistent with previous reports of low conversion of glucose into lactate under normal physiological conditions 11,56

The elimination of organelles evolved to provide more space for oxygen-carrying hemoglobin and to maintain the biconcave shape of RBCs [32]

Endothelial dysfunction may lead to impaired vasoconstriction, affecting microcirculatory blood flow, exacerbating tissue perfusion deficits in septic patients, and ultimately resulting in multi-organ failure

Published 2023 Apr 13

For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes