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This is a dual-action effect: it builds new collagen while simultaneously protecting existing collagen from degradation

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current strategies often disrupt normal mitochondrial function in healthy tissues, and biomarkers to stratify patients likely to respond to such therapies (based on mitochondrial ferroptosis signatures) are still absent

Therefore, leucine represents the BCAA with the most compelling mechanistic and clinical evidence relevant to musclevascular interactions and healthy aging, justifying its emphasis in the present review