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A higher power output (such as in a sub-ohm vape) will generally make a louder noise, but it won't last as long with a sub-ohm device

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comparing the acute impact of tobacco versus e-cigarettes with equivalent nicotine content, found that within 5 min of smoking or vaping, both tobacco smokers and healthy individuals exhibited a statistically significant increase in sCD40L, sP-selectin, and platelet aggregation levels in a single-blind crossover trial (40)