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But as Herman Waldmann, one of Lefkovits' collaborators, points out the weakness with their method was that it 'was looking downstream of the original precursor cell.' The difficulty was that they had shown the plasma cell made only one antibody without establishing precommitment to an antigen on the part of precursor or parent cells

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Where the gaps still are

KEGG Mapper for inferring cellular functions from protein sequences

The first, denoted as the Eulerian approach (or pseudo-Lagrangian), converts a series of Lagrangian positions into Eulerian velocity by determining the change in drifter position over some time scale (Hernandez et al

5 a,b,c, reveal a pronounced concentration-dependent and time-dependent antifungal effect