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Citation10,Citation11 Peroxisome proliferator-activated receptor coactivator 1 (PGC-1), a central integrator of multiple signaling pathways, has been demonstrated to play a key role in the regulation of mitochondrial biogenesis and oxidative stress by a mitochondrial transcription factor A (TFAM)

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Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases