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Likewise, caffeic acid itself directly inhibited ERK1/2 (MAPK) activity in melanoma and epidermoid carcinoma cells, disrupting a key pathway that promotes tumor growth and migration (150)

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GHK initiates the cellular downstream pathway and exerts bioactivities through binding with cell surface receptors ( In vitro and in vivo studies proved that this combination stimulates the synthesis of collagen and glycosaminoglycans (Figure 1), respectively