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The binding of active androgens to AR can stimulate macrophages to secrete pro-inflammatory factors IL-1, IL-6, and TNF- (105), which is consistent with the inflammatory response observed at acne lesion sites

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Thus the data might suggest that the H

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and a reduced IGF action, parallel to increased cortisol levels, results in a smaller number of glomeruli[198]

Deveci S, Palese M, Parker M, Guhring P, Mulhall JP