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In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings

About 15 percent of adults above 65 years have subclinical deficiency, probably contributed to by the use of H2-receptor blockers for hyperacidity treatment, since these also reduce cobalamine levels

doi: 10.1039/D1RA06266B

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