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Liao H, Wang X, Yang C et al (2025) Overexpression of colonic VIP ameliorates cognitive function and barrier system damage caused by sevoflurane anesthesia and surgery in aged rats with fragile brain functions

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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs

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This is one of the reasons we insist on a licensed provider intake rather than a direct-to-consumer model