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The consumption of acetyl-CoA in irreversible metabolic pathways, i.e., lipoic acid and citrate synthesis within the mitochondria followed by biosynthetic processes within the cytosol (Figure 1), drives the process and maintains the mitochondrial content of acetyl-CoA within a safe range

& Inoue, S

Gdel and H

Improves firmness and visible lift

In Figure 1 is reported a simplified schema of these two main branches of the non-protein TRP metabolism in humans, also showing their interplays with energy metabolism (KYN paths), neurotransmission/inflammation (5-HT and KYN path in opposite direction) and circadian pacemakers (MLT)