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Another miRNA among these, miR-139-5p, was previously described as one of the most downregulated miRNAs in CRC tissues, and in vitro studies demonstrated that miR-139-5p overexpression led to a remarkable reduction in CRC cell migration and invasion, without affecting cell proliferation (89)

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Lin Y, Li C, Chen Y, Gao J, Li J, Huang C, Liu Z, Wang W, Zheng X, Song X, Wu J, Wu J, Luo OJ, Tu Z, Li S, Li XJ, Lai L, Yan S (2025) RNA-targeting CRISPR/CasRx system relieves disease symptoms in Huntingtons disease models

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In contrast, 100% of a pure L-selenomethionine source can be used for both pathways in the metabolism