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RA SF samples featured disturbed phenylalanine, tyrosine, and tryptophan biosynthesis pathway and high levels of o-tyrosine, a structural isomer of p-tyrosine derived from non-enzymatic free-radical hydroxylation of phenylalanine under increased oxidative stress [17]

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reported that the expression level of asparagine synthetase (ASNS) in breast cancer is closely related to metastatic recurrence and that inhibition of ASNS or restriction of dietary Asn can reduce tumor metastasis

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