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Proc Natl Acad Sci U S A 2011;108:21069-74

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This response may be part of an emergency response with the sudden onslaught of oxidants from the CS exposure or it may be the depletion of GSH during the CS exposure combined with the increase in oxidants from CS that acts as a trigger to initiate this response

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Furthermore, experimental OECD TG471-compliant mutagenicity testing requires NA-specific adaptation of the standard protocols (Organisation for Economic Co-operation and Development 2020), as the sensitivity of the standard OECD TG471 Ames test has been questioned for NAs by regulatory agencies (European Medicines Agency 2025

National Library of Medicine, National Institutes of Health, U.S