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AMPK activators, such as metformin (Nakashima et al., 2022), 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) (Mao et al., 2020), aminophylline (Mao et al., 2020), quercetin (Mitani et al., 2017), and resveratrol (Qi et al., 2014) ameliorate COPD by activating AMPK

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However, there is little doubt that smoking is a male infertility factor and male smokers who are experiencing infertility should quit to improve their chances at successful reproduction