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It disrupts antioxidant defenses by reducing the activity of copper-dependent enzymes, such as CCS, leading to uncontrolled oxidative stress and intensified inflammatory responses [160, 161]

Carriers of a single HbS copy typically have 40% of HbS

The mechanosensitive ion channel PIEZO1 in intestinal epithelial cells mediates inflammation through the NOD-Like receptor 3 pathway in crohns disease

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Meanwhile, naringin suppresses NF-B-mediated inflammation downstream of RAGE activation, thereby modulating the associated pro-inflammatory signaling 24

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