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There are thousands of specific cultivars and dozens of strain families

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Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in african green monkeys after long-term nicotine administration

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At lower smoking rates, there is some evidence of appetite suppression from nicotine and increased metabolic rate

Fruit flavors like citrus and berry offer alternatives for users seeking variety, while coffee and tobacco flavors appeal to those preferring familiar tastes