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Clinical studies show improvements in sleep quality, duration, and nighttime awakenings in 7288% of participants, with no adverse events reported

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Another 2020 review of research on milk thistle concluded silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes

In many instances, a high-dose oral vitamin B12 supplement, such as 1,000 mcg (1 mg), provides enough of this vitamin that injections are not necessary

Fasting is usually unnecessary, although some clinicians prefer avoiding supplements shortly before testing.

Protein from meat, fish, and legumes helps provide the building blocks the liver needs