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What it does establish is biological plausibility for restoration: putting back what the body has lost is a more conservative pharmacological proposition than overdriving a healthy system

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

M.Correia GuedesL.CoelhoM.RosaM

40 In addition to the above regulatory factors, crosstalk between Wnt/-catenin and other pathways also regulates canonical Wnt signalling in different ways (Table 4)