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6.3 Ferroptosis of astrocytes promotes atherosclerosis Astrocytesthe most abundant and largest class of glial cells in the mammalian brainmaintain and divide neuronal cells, aid in creating the blood-brain barrier, and regulate the onset of several disease processes (Khakh and Sofroniew, 2015)

When the system X c - is dysfunctional or inhibited, the levels of cysteine and GSH inside the cell decrease, leading to an exacerbation of intracellular oxidative stress, resulting in the accumulation of lipid peroxides and ultimately triggering ferroptosis ( c - can help in maintaining intracellular redox balance, inhibiting the occurrence of ferroptosis, and potentially have therapeutic effects for various diseases, such as cerebral ischemia-reperfusion injury (CIRI) ( 2.2.2 FSP1/CoQ10/NADPH pathway Ferroptosis suppressor protein 1(FSP1) is a protein capable of participating in iron-sulfur cluster modifications, transferring iron-sulfur clusters from mitochondria to target proteins (72)

P., Pergande, G

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The mixture was incubated at room temperature for 10 min