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4) Environmental Toxicities: Mold/mycotoxins, heavy metals, and chemicals like glyphosate are all known "mitochondrial poisons" that disrupt ATP production and cause chronic fatigue

Ren et al., 2021

The addition of PI3K inhibitors, including, MK2206, LY294002, IC87114, idelalisib, and TGR-1202, during expansion has been shown to maintain CAR T cells in a less differentiated state leading to increased downstream anti-tumor efficacy and persistence of CAR T cells in vivo (105, 121, 158)