smoking one cigarette a year kills. Tobacco causes around 8 million deaths every year, including more than 1 million linked to second-hand smoke exposure. Quitting is possible — and the longer you stay tobacco-free, the healthier No Safe Level of Smoking

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According to the third SR (25 studies), active smoking increases the risk of severe asthma exacerbations and of suboptimal asthma control (moderate certainty evidence) and may impact asthmarelated qualityoflife and LF (low certainty evidence)

All other tobacco products are taxed at 24% of the wholesale price.6,7 Clean indoor air ordinances Smoking is prohibited in all government workplaces, private workplaces, schools, childcare facilities, restaurants, retail stores (retail tobacco and cigar specialty stores exempt) and recreational/cultural facilities.6,7 Smoking restrictions are required in bars.6,7 There are no smoking restrictions in casinos/gaming establishments.6,7 There are no smoke-free restrictions for e-cigarette use.9 Licensing laws Retailers and wholesalers are required to obtain a license to sell tobacco products.6 A license is required to sell e-cigarette products.9 Youth access laws Effective December 2019, the United States adopted a law raising the federal minimum age of sale of all tobacco products to 21

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Functional role of T17 cells in ameliorating airflow limitation and the emphysema-like phenotype To explore the functional role of T cells under tobacco smoke exposure, we used an in vitro expansion method 17 to generate T17 cells (Supplementary Fig