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Neuropeptide-induced MCs degranulation leads to release of pruritogenic mediators, which further sensitize neurons and promote additional neuropeptide release ( + subsets, have been shown to tonically release glutamate, thereby restraining MCs hyperresponsiveness through regulation of Mrgprb2 expression (115)

Key Facts about Tobacco and Its Health Impacts Tobacco, a central component in a variety of smoking products, carries significant health impacts that are crucial to understand

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Given the rapidity with which ECs evolve, there may be additional chemicals or coolants that become industry standards, further increases in puff numbers, or a completely new generation that will emerge from current disposable ECs

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