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We used Cox proportional hazards models, adjusted for age, race/ethnicity, marital status, education, income and region to estimate hazard ratios (HRs, 95% confidence intervals, CI) for mortality from all causes, heart diseases, malignant neoplasms, cerebrovascular disease, chronic lower respiratory diseases and two mutually exclusive categories: smoking-related and other diseases

The tobacco blend, the size, the filter tip, the package, the carton and the advertising, a Reynolds spokesman said, were all designed to appeal to the woman smoker. Packaging innovations with a special appeal to women include a package that is half-way between the normal soft pack and a flip-top box, a self-locking flap that closes over the cigarettes to keep loose tobacco from falling out in purses, and embossing that gives the entire package the feel of a fabric cigarette case

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By the 1970s, even those failed government restrictions managed to have some effect

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