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2.9 Joint analysis of the transcriptome and metabolome Based on the transcriptomic and metabolomic data, the KEGG signaling pathways in which the DEGs and DEMs were co-enriched were further analyzed

In IC, TGF- fails to effectively mediate tissue regeneration, leading to fibroblast activation and fibrosis, which further inhibits cell proliferation (Mormone et al., 2024)

Libraries for RNA-seq were prepared from total RNA as previously described [13]

doi: 10.1016/j.cis.2020.102336 74 KuangZ.BennettR

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1) compared to the findings of Teanovi et al