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Selenoprotein polymorphisms are a risk factor for the development of systolic heart failure (HF) and peripheral atherosclerosis but prevent the development of abdominal aortic aneurysm (AAA)

American Journal of Physiology-Gastrointestinal and Liver Physiology

GPX4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress

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Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestine