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Expressions of cleaved Caspase-1, GSDMD-NT, IL-18, and the secretion of IL-1 are also increased in the kidneys of db/db mice (127)

The same method was used to measure in vivo brain levels of lactate and N-acetylaspartate (NAA) as markers of mitochondrial dysfunction

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For example, Cas9 can successfully introduce DSBs at specific sites to introduce small insertions or deletions (indels) into the genome, and the introduced DSBs cause the formation of gene byproducts that disturb intracellular genome stability

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For example, severe systemic G6PD deficiency predisposes to bacterial and fungal infections, while Pgd knockout in T cells putatively promotes antitumour immunity 121