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Long before cancer was understood as a disease of mutated genesindeed, long before the terms gene and DNA entered our scientific vocabularya London physician named Percivall Pott wrote about the cancerous scrotal sores that were turning up in chimney sweeps, who, since early childhood, had been thrust up narrow, and sometimes hot chimneys, where they are bruised, burned, and almost suffocated. Although the condition was initially attributed to a venereal diseasewhat better explanation for a poor mans genital lesions than his presumed promiscuity?Pott conjectured, in a 1775 essay, that the soot-wart was caused by chronic exposure to soot particles, which lodged in the scrotal ridges