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To address heterogeneity and missing values inherent in multi-omic datasets, emerging deep-learning models such as IMOVNN have been deployed to impute incomplete data, facilitating disease prediction and the identification of critical biomarkers [565]

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In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes