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Front Endocrinol (2022) 13:930756

, and Rothman D

Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis

Indeed, preclinical and clinical studies evidence beneficial effects of trimetazidine not only on mitochondrial energy metabolism but also on inflammation and oxidative stress compared to saline or vehicle [131, 132]